SAN FRANCISCO -- Even with standouts Bryce Harper and Gio Gonzalez on the disabled list, the Washington Nationals are shutting down the team with the best record in baseball and taking over the title as the leagues hottest club. Jayson Werth hit his first homer in almost a month and drove in three runs, and the Nationals capitalized on Matt Cains erratic start to beat the San Francisco Giants 6-2 Wednesday night for their fourth straight win. "We kind of got Cain on the ropes early, got his pitch count up, got some big hits early to kind of set the tone for the game," Werth said. "Its hard to recover from." Cain (1-4) walked the first three batters he faced before Adam LaRoches two-run single during a three-run first inning. Werths solo shot in the fifth and two-run single in the ninth provided the rest of the pop for the Nationals, who have won 10 of 12, including the last three at San Francisco. Former third baseman Ryan Zimmerman made a pair of diving catches in left field to highlight a stellar defensive effort, and Tanner Roark (5-4) allowed two runs and seven hits in six-plus innings to propel Washington to another win. "Were playing great as a team right row," said Roark, who struck out four and walked none. "Just keep it going. Its exciting." Brandon Crawford and Pablo Sandoval each drove in a run for the Giants, who have lost a season-high tying three straight after winning five in a row. Cains struggles might have been the most disappointing thing of all for the Giants. In his second start since a stint on the disabled list with a strained right hamstring, the former ace reverted back to his early season woes against Washington. Cain gave up four runs and three hits in five innings, walking five and striking out four. "It was too much of a deficit to come back from. We needed a better start than that. I wanted some clean innings. I made it too difficult," Cain said. The finale of the four-game series is Thursday, but the NL East-leading Nationals already have handed San Francisco its first series loss since losing two of three at Pittsburgh from May 5-7. Before the Nationals showed up in San Francisco this week, the Giants had not lost two in a row since May 16-17 to the Marlins. The Nationals are doing it by getting contributions at the plate, on the mound and in the field. After Crawfords RBI triple in the fourth, second baseman Danny Espinosa made a diving stop on Gregor Blancos sharp grounder and threw out the speedy runner at first. Zimmerman, filling in for Harper in left, also swiped another run from San Francisco in the sixth when he made a diving catch of Crawfords slicing fly after Michael Morse doubled. "Im kind of learning on the fly," Zimmerman said. "Got a good break on it. It kept tailing away. I dove and caught it. The landing wasnt very smooth, but in the end, I caught the ball." Sandoval, scratched from the starting lineup because of an illness, singled home a run as a pinch-hitter in the seventh to whittle Washingtons lead to 4-2. Zimmerman slid in to snag Angel Pagans short fly for the third out. With his back right leg almost touching the dirt, Werth went low to launch his sixth homer of the season to put the Nationals up 4-1 in the fifth. Werth, who had not homered since May 14 at Arizona, singled with two outs in the ninth off Yusmeiro Petit to extend Washingtons lead to 6-2. Drew Storen, Tyler Clippard and Jerry Blevins each tossed a scoreless inning to help Washington finish off San Francisco again. Closer Rafael Soriano had been warming up in the bullpen before Werths single. "The best part about that is we could put the big scary guy back in his cage," Werth said, "and save him for (Thursday)." NOTES: The Nationals placed catcher Wilson Ramos on the 15-day disabled list with a strained right hamstring and called up catcher Sandy Leon from Triple-A Syracuse. ... The Giants traded left-hander David Huff back to the Yankees for cash. He was sent to San Francisco in January for cash after the Yankees signed Masahiro Tanaka. ... Tim Hudson (6-2, 1.97 ERA) takes the mound for the Giants opposite Washingtons Blake Treinen (0-2, 1.78 ERA) in Thursdays series finale. Joe Namath Jets Jersey .Y. - Geno Smith still thinks of himself as the New York Jets starting quarterback. Jachai Polite Womens Jersey . James scored 25 points against his former team, leading the energized Heat to a 114-107 victory over the Cleveland Cavaliers on Saturday night. Dwyane Wade added 24 points and Chris Bosh had 22 for the Heat, idle since a 90-84 loss Tuesday at Indiana. http://www.jetsrookiestore.com/Jets-Dennis-Byrd-Jersey/ . Sami Vatanen had a goal and an assist and Anaheim used a four-goal first period to extend their winning streak to six games with a 5-2 win over the Detroit Red Wings on Tuesday night. Jachai Polite Jersey . Pedroia reached the milestone with a little panache, hitting a grand slam in the sixth inning and propelling the Boston Red Sox to a 7-1 win over the Oakland Athletics on Friday night. Mark Gastineau Youth Jersey . The Mavericks were not going to let San Antonio beat them with 3-pointers, and they did not want Tony Parker using the lane as his personal playground. Andrew Wiggins and Kansas have been upset. Wichita States undefeated season is over. Watch the road to the Sweet Sixteen today, as TSN2 and TSN GO return with coverage of the NCAA Mens Basketball Championships Round of 32. Coverage is underway on TSN2 now while TSN GO also offers TSN subscribers bonus online coverage, with live streams of all four venues. Sundays Results Dwight Powell had 15 points and seven rebounds and No. 10 seed Stanford wrapped up its second straight upset at the free throw line, knocking off No. 2 Kansas 60-57. Canadian freshman Andrew Wiggins had just four points on 1-for-6 shooting with four turnovers in his final college game for Kansas (25-10). Wiggins, from Vaughan, Ont., is a likely NBA lottery pick and had averaged 28 points the previous four games. Andrew Harrison converted 3-of-4 foul shots down the stretch and Fred VanVleets contested three-pointer fell short just prior to the buzzer, allowing Kentucky to knock off Wichita State, 78-76. DeAndre Kane drove for the game-winningg layup with 1.dddddddddddd.6 seconds left and No. 3 seed Iowa State beat North Carolina 85-83 on Sunday, advancing to the Sweet 16 for the first time since 2000. Jarnell Stokes had 17 points and a career-high-tying 18 rebounds, and the Tennessee Volunteers denied Mercer a second straight upset in the NCAA tournament by routing the Bears 83-63 on Sunday night. Jordan Adams had 19 points, Norman Powell scored 16 and UCLA moved on to the Sweet 16 for the first time in six years with a 77-60 win over Stephen F. Austin. Isaiah Austin and Canadian Brady Heslip each scored 17 points and Baylor shut down Creightons Doug McDermott with suffocating defence, ending the career of one of college basketballs most prolific scorers with an 85-55 win Sunday night in the NCAA tournament West Regional. Joe Harris had 16 points and five rebounds and the Cavaliers routed Memphis, 78-60, to advance to the Sweet 16 for the first time since 1995. (With files from the Associated Press and SportsNetwork.com) ' ' '